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KMID : 0380620220540060587
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Korean Journal of Food Science and Technology
2022 Volume.54 No. 6 p.587 ~ p.593
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Effects of Causonis japonica (Thunb.) Raf. extract on LPS-induced inflammation in RAW264.7 macrophages, via the NF-kB signaling pathway
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Kang Ha-Yeong
Tran The Bach
Eum Sang-Mi
Jung Sung-Keun
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Abstract
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We evaluated the anti-inflammatory effects of Causonis japonica (Thunb.) Raf. extract (CJE) in mouse RAW264.7 macrophage cells. The CJE significantly suppressed lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS)/nitric oxide (NO) production. It also suppressed LPS-induced phosphorylation of IkB kinase (IKK), p65, the translocation of p65 from the cytosol to the nucleus, and the phosphorylation of mitogen-activated protein kinases (MAPKs). Overall, our results suggested that the CJE suppresses LPS-induced inflammatory responses by regulating the NF-κB and MAPK signaling pathways.
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KEYWORD
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Causonis japonica (Thunb.) Raf. extract (CJE), nitric oxide (NO), NF-κB (nuclear factor kappa-B), mitogen-activated protein kinase (MAPK), anti-inflammatory effect
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